4o1o Summary

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Crystal Structure of RNase L in complex with 2-5A

The structure was published by Huang, H., Zeqiraj, E., Ceccarelli, D.F., and Sicheri, F., in 2014 in a paper entitled "Dimeric structure of Pseudokinase RNase L bound to 2-5A reveals a basis for Interferon-induced antiviral activity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.27 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Ribonuclease L.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ribonuclease L A5H025 (21-732) (A5H025_PIG)search Sus scrofasearch 96% 717 93%
B Ribonuclease L A5H025 (21-732) (A5H025_PIG)search Sus scrofasearch 96% 717 93%
C Ribonuclease L A5H025 (21-732) (A5H025_PIG)search Sus scrofasearch 96% 717 93%
D Ribonuclease L A5H025 (21-732) (A5H025_PIG)search Sus scrofasearch 96% 717 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
A5H025 (21 - 732) Ribonuclease L Sus scrofa

Chain Sequence family (Pfam)
A, B, C, D (A5H025) PF00069: Protein kinase domainsearch, PF06479: Ribonuclease 2-5Asearch, PF12796: Ankyrin repeats (3 copies)search

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D (A5H025) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch metal ion bindingsearch ribonuclease activitysearch protein kinase activitysearch protein phosphorylationsearch mRNA processingsearch RNA phosphodiester bond hydrolysissearch

Chain InterPro annotation
A, B, C, D Protein kinase domainsearch Ankyrin repeatsearch PUG domainsearch KEN domainsearch Protein kinase-like domainsearch Ankyrin repeat-containing domainsearch