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Crystal Structure of RNase L in complex with 2-5A

Source organism: Sus scrofa
Biochemical function: metal ion binding
Biological process: defense response to virus
Cellular component: not assigned

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF12796
Domain description: Ankyrin repeats (3 copies)
Occurring in:
  1. Ribonuclease L
The deposited structure of PDB entry 4o1o contains 16 copies of Pfam domain PF12796 (Ankyrin repeats (3 copies)) in Ribonuclease L. Showing 4 copies in chain A.

PF06479
Domain description: Ribonuclease 2-5A
Occurring in:
  1. Ribonuclease L
The deposited structure of PDB entry 4o1o contains 4 copies of Pfam domain PF06479 (Ribonuclease 2-5A) in Ribonuclease L. Showing 1 copy in chain A.

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Ribonuclease L
The deposited structure of PDB entry 4o1o contains 4 copies of Pfam domain PF00069 (Protein kinase domain) in Ribonuclease L. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002110
Domain description: Ankyrin repeat
Occurring in:
  1. Ribonuclease L
IPR010513
Domain description: KEN domain
Occurring in:
  1. Ribonuclease L
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Ribonuclease L
IPR036770
Domain description: Ankyrin repeat-containing domain superfamily
Occurring in:
  1. Ribonuclease L
IPR042745
Domain description: RNase L, RNase domain
Occurring in:
  1. Ribonuclease L
IPR038357
Domain description: KEN domain superfamily
Occurring in:
  1. Ribonuclease L
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Ribonuclease L

Structure domains

CATH CATH domains
1.20.1440.180
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: de novo design (two linked rop proteins)
Homology: KEN domain
Occurring in:
  1. Ribonuclease L
The deposited structure of PDB entry 4o1o contains 4 copies of CATH domain 1.20.1440.180 (de novo design (two linked rop proteins)) in Ribonuclease L. Showing 1 copy in chain A.
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Ribonuclease L
The deposited structure of PDB entry 4o1o contains 4 copies of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Ribonuclease L. Showing 1 copy in chain A.
1.25.40.20
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Ankyrin repeat-containing domain
Occurring in:
  1. Ribonuclease L
The deposited structure of PDB entry 4o1o contains 4 copies of CATH domain 1.25.40.20 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Ribonuclease L. Showing 1 copy in chain A.

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