4nc5 Summary


Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)

The structure was published by Buchini, S., Gallat, F.X., Greig, I.R., et al., Wakatsuki, S., Chavas, L.M., and Withers, S.G., in 2014 in a paper entitled "Tuning mechanism-based inactivators of neuraminidases: mechanistic and structural insights." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.513 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Sialidase-2. This molecule has the UniProt identifier Q9Y3R4 (NEUR2_HUMAN)search. The sample contained 382 residues which is 100% of the natural sequence. Out of 382 residues 353 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Sialidase-2 Q9Y3R4 (1-380) (NEUR2_HUMAN)search Homo sapienssearch 100% 382 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9Y3R4 (1 - 380) Sialidase-2 Homo sapiens

Chain Sequence family (Pfam)
A (Q9Y3R4) PF13088: BNR repeat-like domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (Q9Y3R4) cytoplasmsearch cytosolsearch exo-alpha-sialidase activitysearch hydrolase activitysearch exo-alpha-(2->6)-sialidase activitysearch exo-alpha-(2->8)-sialidase activitysearch exo-alpha-(2->3)-sialidase activitysearch hydrolase activity, acting on glycosyl bondssearch sphingolipid metabolic processsearch lipid metabolic processsearch lipid catabolic processsearch glycosphingolipid metabolic processsearch carbohydrate metabolic processsearch metabolic processsearch ganglioside catabolic processsearch small molecule metabolic processsearch oligosaccharide catabolic processsearch

Chain InterPro annotation
A Sialidasessearch Sialidase familysearch Sialidase-2search