› 4n8p

X-ray diffraction
2.3Å resolution

Crystal structure of a strand swapped CTLA-4 from Duckbill Platypus [PSI-NYSGRC-012711]

Released:
DOI: 10.2210/pdb4n8p/pdb
PDB entry 4n8p coloured by chain, front view.
PDB entry 4n8p coloured by chain, side view.
PDB entry 4n8p coloured by chain, top view.
Source organism: Ornithorhynchus anatinus
Entry authors: Kumar PR, Banu R, Bhosle R, Calarese DA, Celikgil A, Chamala S, Chan MK, Chowdhury S, Fiser A, Garforth SJ, Glenn AS, Hillerich B, Khafizov K, Attonito J, Love JD, Patel H, Patel R, Seidel RD, Smith B, Stead M, Toro R, Casadevall A, Almo SC, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123657 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxic T-lymphocyte protein 4 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.03 KDa
Source organism: Ornithorhynchus anatinus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: F6ZMI5 (Residues: 45-164; Coverage: 52%)
Gene name: CTLA4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: I212121
Unit cell:
a: 37.272Å b: 107.991Å c: 109.723Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.212
Expression system: Trichoplusia ni

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