4n6h Summary


1.8 A Structure of the human delta opioid 7TM receptor (PSI Community Target)

The structure was published by Fenalti, G., Giguere, P.M., Katritch, V., et al., Cherezov, V., Roth, B.L., and Stevens, R.C., in 2014 in a paper entitled "Molecular control of delta-opioid receptor signalling." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Soluble cytochrome b562, Delta-type opioid receptor chimeric protein. This molecule has the UniProt identifier P0ABE7 (C562_ECOLX)search. The sample contained 414 residues which is 100% of the natural sequence. Out of 414 residues 397 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Soluble cytochrome b562, Delta-type opioid receptor chimeric protein P0ABE7 (23-128) (C562_ECOLX)search ,
P41143 (36-338) (OPRD_HUMAN)search
Escherichia colisearch ,
Homo sapienssearch
99% ,
< 90%
414 98%

Chain Sequence family (Pfam)
A (P0ABE7) PF07361: Cytochrome b562search

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P0ABE7P41143) integral component of membranesearch periplasmic spacesearch G-protein coupled receptor signaling pathwaysearch electron transport chainsearch oxidation-reduction processsearch heme bindingsearch electron carrier activitysearch G-protein coupled receptor activitysearch opioid receptor activitysearch iron ion bindingsearch metal ion bindingsearch enkephalin receptor activitysearch

Chain InterPro annotation
A G protein-coupled receptor, rhodopsin-likesearch Delta opioid receptorsearch Opioid receptorsearch Cytochrome b562search Cytochrome c/b562search GPCR, rhodopsin-like, 7TMsearch