4mze Summary

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Crystal structure of hPIV3 hemagglutinin-neuraminidase, H552Q/Q559R mutant

The structure was published by Xu, R., Palmer, S.G., Porotto, M., et al., Niewiesk, S., Wilson, I.A., and Moscona, A., in 2013 in a paper entitled "Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Hemagglutinin-neuraminidase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemagglutinin-neuraminidase P08492 (136-572) (HN_PI3H4)search Human parainfluenza 3 virus (strain NIH 47885)search < 90% 437 98%
B Hemagglutinin-neuraminidase P08492 (136-572) (HN_PI3H4)search Human parainfluenza 3 virus (strain NIH 47885)search < 90% 437 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08492 (136 - 572) Hemagglutinin-neuraminidase Human parainfluenza 3 virus (strain NIH 47885)

Chain Sequence family (Pfam)
A, B Haemagglutinin-neuraminidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P08492) viral life cyclesearch exo-alpha-sialidase activitysearch host cell surface receptor bindingsearch viral envelopesearch

Chain InterPro annotation
A, B Haemagglutinin-neuraminidasesearch Sialidasessearch