4mqw Summary

pdbe.org/4mqw
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Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)

The structure was published by Jiang, X., Fischer, D., Chen, X., et al., Goutopoulos, A., Arkinstall, S., and He, X., in 2014 in a paper entitled "Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Glycoprotein hormones, alpha polypeptide, Follitropin subunit beta, and Follicle-stimulating hormone receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycoprotein hormones, alpha polypeptide P01215 (25-116) (GLHA_HUMAN)search Homo sapienssearch 100% 102 87%
D Glycoprotein hormones, alpha polypeptide P01215 (25-116) (GLHA_HUMAN)search Homo sapienssearch 100% 102 87%
G Glycoprotein hormones, alpha polypeptide P01215 (25-116) (GLHA_HUMAN)search Homo sapienssearch 100% 102 87%
B Follitropin subunit beta P01225 (19-129) (FSHB_HUMAN)search Homo sapienssearch 100% 111 98%
E Follitropin subunit beta P01225 (19-129) (FSHB_HUMAN)search Homo sapienssearch 100% 111 98%
H Follitropin subunit beta P01225 (19-129) (FSHB_HUMAN)search Homo sapienssearch 100% 111 98%
X Follicle-stimulating hormone receptor P23945 (16-366) (FSHR_HUMAN)search Homo sapienssearch < 90% 361 80%
Y Follicle-stimulating hormone receptor P23945 (16-366) (FSHR_HUMAN)search Homo sapienssearch < 90% 361 80%
Z Follicle-stimulating hormone receptor P23945 (16-366) (FSHR_HUMAN)search Homo sapienssearch < 90% 361 80%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01215 (25 - 116) Glycoprotein hormones, alpha polypeptide Homo sapiens
P01225 (19 - 129) Follitropin subunit beta Homo sapiens
P23945 (16 - 366) Follicle-stimulating hormone receptor Homo sapiens

Chain Sequence family (Pfam)
A, D, G (P01215) PF00236: Glycoprotein hormonesearch
B, E, H (P01225) PF00007: Cystine-knot domainsearch
X, Y, Z Leucine rich repeat N-terminal domainsearch, Gonadotropin hormone receptor transmembrane regionsearch, Leucine rich repeatsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, D, G (P01215) extracellular regionsearch hormone activitysearch protein bindingsearch peptide hormone processingsearch thyroid hormone generationsearch negative regulation of organ growthsearch gonad developmentsearch luteinizing hormone secretionsearch positive regulation of cell migrationsearch positive regulation of cell proliferationsearch positive regulation of transcription from RNA polymerase II promotersearch cell-cell signalingsearch cellular response to hormone stimulussearch cellular protein metabolic processsearch follicle-stimulating hormone secretionsearch developmental growthsearch signal transductionsearch thyroid gland developmentsearch
B, E, H (P01225) extracellular vesicular exosomesearch extracellular regionsearch cytoplasmsearch protein bindingsearch hormone activitysearch positive regulation of cell migrationsearch progesterone biosynthetic processsearch positive regulation of cell proliferationsearch regulation of osteoclast differentiationsearch Sertoli cell proliferationsearch ovarian follicle developmentsearch cellular protein metabolic processsearch female gamete generationsearch female pregnancysearch follicle-stimulating hormone signaling pathwaysearch peptide hormone processingsearch transforming growth factor beta receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch signal transductionsearch positive regulation of bone resorptionsearch
X, Y, Z (P23945) integral component of membranesearch follicle-stimulating hormone receptor activitysearch protein-hormone receptor activitysearch G-protein coupled receptor signaling pathwaysearch

Chain InterPro annotation
A, D, G Glycoprotein hormone alpha chainsearch Cystine-knot cytokinesearch
B, E, H Gonadotropin, beta subunitsearch Glycoprotein hormone subunit beta, cystine knotsearch Gonadotropin, beta subunit, conserved sitesearch Cystine-knot cytokinesearch
X, Y, Z Leucine-rich repeat-containing N-terminalsearch Leucine-rich repeatsearch Glycoprotein hormone receptor familysearch Follicle stimulating hormone receptorsearch Gonadotropin hormone receptor, transmembrane domainsearch