4mjv Summary


Influenza Neuraminidase in complex with a novel antiviral compound

The structure was published by Mohan, S., Kerry, P.S., Bance, N., Niikura, M., and Pinto, B.M., in 2014 in a paper entitled "Serendipitous discovery of a potent influenza virus a neuraminidase inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.65 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Neuraminidase. This molecule has the UniProt identifier Q07599 (NRAM_I63A3)search. The sample contained 390 residues which is < 90% of the natural sequence. Out of 390 residues 389 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Neuraminidase Q07599 (81-470) (NRAM_I63A3)search Influenza A virus (A/duck/Ukraine/1/1963(H3N8))search < 90% 390 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q07599 (81 - 470) Neuraminidase Influenza A virus (A/duck/Ukraine/1/1963(H3N8))

Chain Sequence family (Pfam)
A Neuraminidasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q07599) carbohydrate metabolic processsearch host cell membranesearch virion membranesearch membranesearch exo-alpha-sialidase activitysearch

Chain InterPro annotation
A Glycoside hydrolase, family 34search Sialidasessearch