4mjq Summary

pdbe.org/4mjq
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E. coli sliding clamp in complex with Bromfenac

The structure was published by Yin, Z., Wang, Y., Whittell, L.R., et al., Kelso, M.J., Beck, J.L., and Oakley, A.J., in 2014 in a paper entitled "DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.73 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of DNA polymerase III subunit beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DNA polymerase III subunit beta P0A988 (1-366) (DPO3B_ECOLI)search Escherichia coli K-12search 100% 366 99%
B DNA polymerase III subunit beta P0A988 (1-366) (DPO3B_ECOLI)search Escherichia coli K-12search 100% 366 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A988 (1 - 366) DNA polymerase III subunit beta Escherichia coli K-12

Chain Sequence family (Pfam)
A, B (P0A988) PF00712: DNA polymerase III beta subunit, N-terminal domainsearch, PF02767: DNA polymerase III beta subunit, central domainsearch, PF02768: DNA polymerase III beta subunit, C-terminal domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P0A988) DNA polymerase III complexsearch cytoplasmsearch cytosolsearch DNA replicationsearch DNA biosynthetic processsearch cellular response to DNA damage stimulussearch DNA strand elongation involved in DNA replicationsearch nucleic acid phosphodiester bond hydrolysissearch 3'-5' exonuclease activitysearch DNA-directed DNA polymerase activitysearch DNA bindingsearch identical protein bindingsearch protein bindingsearch transferase activitysearch nucleotidyltransferase activitysearch

Chain InterPro annotation
A, B DNA polymerase III, beta chainsearch DNA polymerase III, beta chain, N-terminalsearch DNA polymerase III, beta chain, C-terminalsearch DNA polymerase III, beta chain, centralsearch