› 4mj6

X-ray diffraction
2.57Å resolution

Crystal Structure of HLA-A*1101 in complex with H7-22, an influenza A(H7N9) virus epitope

Released:
DOI: 10.2210/pdb4mj6/pdb
PDB entry 4mj6 coloured by chain, front view.
PDB entry 4mj6 coloured by chain, side view.
PDB entry 4mj6 coloured by chain, top view.
Source organisms:
Primary publication:
Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions.
Liu WJ, Tan S, Zhao M, Quan C, Bi Y, Wu Y, Zhang S, Zhang H, Xiao H, Qi J, Yan J, Liu W, Yu H, Shu Y, Wu G, Gao GF
J Infect Dis 214 1937-1946 (2016)
PMID: 27738054

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137829 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Nucleoprotein Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.37 KDa
Source organism: Influenza A virus (A/chicken/Soc Trang/4/2012(H5N1))
Expression system: Not provided
UniProt:
  • Canonical: Q9Q0U8 (Residues: 188-198; Coverage: 2%)
Gene name: NP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 54.993Å b: 65.052Å c: 109.739Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.186 0.247
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 review citations

Human T-cell immunity against the emerging and re-emerging viruses.
Zhao et al. (2017)
3 more

1 mention without citation

A Glimpse of the Peptide Profile Presentation by Xenopus laevis MHC Class I: Crystal Structure of pXela-UAA Reveals a Distinct Peptide-Binding Groove.
Ma et al. (2020)