4mdh Summary

pdbe.org/4mdh
spacer

PDB entry 4mdh (supersedes 2mdh)

REFINED CRYSTAL STRUCTURE OF CYTOPLASMIC MALATE DEHYDROGENASE AT 2.5-ANGSTROMS RESOLUTION

The structure was published by Birktoft, J.J., Rhodes, G., and Banaszak, L.J., in 1989 in a paper entitled "Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1989.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYTOPLASMIC MALATE DEHYDROGENASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYTOPLASMIC MALATE DEHYDROGENASE P11708 (2-334) (MDHC_PIG)search Sus scrofasearch 100% 334 100%
B CYTOPLASMIC MALATE DEHYDROGENASE P11708 (2-334) (MDHC_PIG)search Sus scrofasearch 100% 334 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11708 (2 - 334) CYTOPLASMIC MALATE DEHYDROGENASE Sus scrofa

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P11708) LDH N-terminal domain-likesearch, Lactate & malate dehydrogenases, C-terminal domainsearch NAD(P)-binding Rossmann-like Domainsearch, L-2-Hydroxyisocaproate Dehydrogenase, subunit A, domain 2search PF00056: lactate/malate dehydrogenase, NAD binding domainsearch, PF02866: lactate/malate dehydrogenase, alpha/beta C-terminal domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P11708) oxidation-reduction processsearch cellular carbohydrate metabolic processsearch carbohydrate metabolic processsearch malate metabolic processsearch tricarboxylic acid cyclesearch cytoplasmsearch cytosolsearch catalytic activitysearch oxidoreductase activitysearch oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorsearch L-malate dehydrogenase activitysearch malate dehydrogenase activitysearch

Chain InterPro annotation
A, B Lactate/malate dehydrogenase, N-terminalsearch Malate dehydrogenase, active sitesearch L-lactate/malate dehydrogenasesearch Malate dehydrogenase, type 2search Malate dehydrogenase, NAD-dependent, cytosolicsearch Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminalsearch NAD(P)-binding domainsearch Lactate/malate dehydrogenase, C-terminalsearch