4m9n Summary

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DNA Polymerase Beta E295K Soaked with dATP

The structure was published by Eckenroth, B.E., Towle-Weicksel, J.B., Sweasy, J.B., and Doublie, S., in 2013 in a paper entitled "The E295K Cancer Variant of Human Polymerase beta Favors the Mismatch Conformational Pathway during Nucleotide Selection." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.275 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DNA polymerase beta P06746 (1-335) (DPOLB_HUMAN)search Homo sapienssearch 97% 335 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06746 (1 - 335) DNA polymerase beta Homo sapiens

Chain Sequence family (Pfam)
A (P06746) PF10391: Fingers domain of DNA polymerase lambdasearch, PF14716: Helix-hairpin-helix domainsearch, PF14791: DNA polymerase beta thumbsearch, PF14792: DNA polymerase beta palmsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P06746) base-excision repair, gap-fillingsearch base-excision repairsearch DNA replicationsearch nucleotide-excision repair, DNA gap fillingsearch response to ethanolsearch DNA repairsearch cellular response to DNA damage stimulussearch pyrimidine dimer repairsearch DNA biosynthetic processsearch neuron apoptotic processsearch DNA-dependent DNA replicationsearch intrinsic apoptotic signaling pathway in response to DNA damagesearch metal ion bindingsearch enzyme bindingsearch protein bindingsearch DNA bindingsearch DNA-directed DNA polymerase activitysearch transferase activitysearch nucleotidyltransferase activitysearch damaged DNA bindingsearch DNA polymerase activitysearch microtubule bindingsearch lyase activitysearch nucleoplasmsearch cytoplasmsearch spindle microtubulesearch nucleussearch microtubulesearch

Chain InterPro annotation
A DNA polymerase family X, beta-likesearch DNA-directed DNA polymerase Xsearch Helix-hairpin-helix DNA-binding motif, class 1search DNA polymerase beta-like, N-terminal domainsearch DNA polymerase lambda, fingers domainsearch DNA polymerase family X, binding sitesearch DNA polymerase family Xsearch DNA polymerase beta, N-terminal domainsearch DNA polymerase beta, palm domainsearch DNA polymerase beta, thumb domainsearch