4m5o Summary details

pdbe.org/4m5o/summary_details
spacer 3-HYDROXY-6-PHENYL-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 H1N1 endonuclease
Summary
Header RNA BINDING PROTEIN/INHIBITORsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.0 Å, R-factor: 18.38%, Free R-factor: 21.84%, Spacegroup: C 2 2 21
Released 18/09/2013, deposition: 08/08/2013, last revision: 11/12/2013
Authors Bauman, J.D.search; Patel, D.search; Das, K.search; Arnold, E.search
Primary citation Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.
ACS CHEM.BIOL.search vol:8, pag:2501-2508 (2013) [PubMed 23978130 ]search
Keywords CAP-SNATCHINGsearch, RNA BINDING PROTEIN-INHIBITOR complexsearch
Organism Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1)) 985958search(A)
Solvent A
Related entries 4ln7, 4m5q, 4m5r, 4m5u, 4m5v, 4mk1, 4mk2, 4mk5
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A Polymerase PA Protein
241 82%
Heterogens
Chain Id Name Ligands
A MANGANESE (II) ION MN search
A SULFATE ION SO4 search
A 1,2-ETHANEDIOL EDO search
A 3-HYDROXY-6-PHENYLPYRIDIN-2(5H)-ONE X48 search
spacer