4m11 Summary

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Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam

The structure was published by Xu, S., Hermanson, D.J., Banerjee, S., et al., Clayton, G.M., Garavito, R.M., and Marnett, L.J., in 2014 in a paper entitled "Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.45 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 2 Q05769 (18-569) (PGH2_MOUSE)search Mus musculussearch 94% 552 100%
B Prostaglandin G/H synthase 2 Q05769 (18-569) (PGH2_MOUSE)search Mus musculussearch 94% 552 100%
C Prostaglandin G/H synthase 2 Q05769 (18-569) (PGH2_MOUSE)search Mus musculussearch 94% 552 100%
D Prostaglandin G/H synthase 2 Q05769 (18-569) (PGH2_MOUSE)search Mus musculussearch 94% 552 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 569) Prostaglandin G/H synthase 2 Mus musculus

Chain Sequence family (Pfam)
A, B, C, D (Q05769) PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (Q05769) response to oxidative stresssearch oxidation-reduction processsearch bone mineralizationsearch response to lithium ionsearch hair cyclesearch regulation of cell proliferationsearch prostaglandin biosynthetic processsearch negative regulation of cell proliferationsearch response to lipopolysaccharidesearch cyclooxygenase pathwaysearch response to organic cyclic compoundsearch fatty acid biosynthetic processsearch positive regulation of fever generationsearch embryo implantationsearch cellular response to ATPsearch cellular response to mechanical stimulussearch response to organonitrogen compoundsearch positive regulation of smooth muscle cell proliferationsearch negative regulation of cell cyclesearch negative regulation of calcium ion transportsearch positive regulation of fibroblast growth factor productionsearch regulation of blood pressuresearch positive regulation of vasoconstrictionsearch response to vitamin Dsearch keratinocyte differentiationsearch prostaglandin metabolic processsearch response to tumor necrosis factorsearch brown fat cell differentiationsearch negative regulation of smooth muscle contractionsearch sensory perception of painsearch response to fructosesearch angiogenesissearch positive regulation of cell deathsearch memorysearch negative regulation of synaptic transmission, dopaminergicsearch response to cytokinesearch positive regulation of apoptotic processsearch positive regulation of smooth muscle contractionsearch response to radiationsearch cellular response to UVsearch positive regulation of brown fat cell differentiationsearch lipid metabolic processsearch fatty acid metabolic processsearch cellular response to hypoxiasearch anagensearch response to fatty acidsearch learningsearch positive regulation of NF-kappaB import into nucleussearch maintenance of blood-brain barriersearch positive regulation of transforming growth factor beta productionsearch inflammatory responsesearch positive regulation of synaptic transmission, glutamatergicsearch positive regulation vascular endothelial growth factor productionsearch response to manganese ionsearch response to glucocorticoidsearch positive regulation of synaptic plasticitysearch response to drugsearch ovulationsearch positive regulation of nitric oxide biosynthetic processsearch decidualizationsearch positive regulation of platelet-derived growth factor productionsearch response to organic substancesearch positive regulation of cell migration involved in sprouting angiogenesissearch response to estradiolsearch peroxidase activitysearch heme bindingsearch dioxygenase activitysearch prostaglandin-endoperoxide synthase activitysearch lipid bindingsearch protein homodimerization activitysearch enzyme bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch oxidoreductase activitysearch metal ion bindingsearch neuron projectionsearch organelle membranesearch protein complexsearch intracellular membrane-bounded organellesearch endoplasmic reticulum membranesearch cytoplasmsearch endoplasmic reticulumsearch membranesearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search