› 4lwo

X-ray diffraction
2.2Å resolution

Crystal structure of PRMT6

Released:
DOI: 10.2210/pdb4lwo/pdb
PDB entry 4lwo coloured by chain, front view.
PDB entry 4lwo coloured by chain, side view.
PDB entry 4lwo coloured by chain, top view.
Source organism: Trypanosoma brucei brucei TREU927
Primary publication:
Crystal structure of arginine methyltransferase 6 from Trypanosoma brucei.
Wang C, Zhu Y, Chen J, Li X, Peng J, Chen J, Zou Y, Zhang Z, Jin H, Yang P, Wu J, Niu L, Gong Q, Teng M, Shi Y
PLoS One 9 e87267 (2014)
PMID: 24498306

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176526 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginine N-methyltransferase, putative Chains: A, B, E, G
Molecule details ›
Chains: A, B, E, G
Length: 368 amino acids
Theoretical weight: 41.26 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli
UniProt:
  • Canonical: Q57U70 (Residues: 1-368; Coverage: 100%)
Gene names: Tb05.6E7.1000, Tb927.5.3960
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 73.903Å b: 143.256Å c: 75.603Å
α: 90° β: 96.67° γ: 90°
R-values:
R R work R free
0.204 0.202 0.249
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.
Stopa et al. (2015)
4 more

3 mentions without citation

Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level.
Tewary et al. (2019)
2 more