› 4lpf

X-ray diffraction
2.3Å resolution

Crystal structure of Mycobacterium tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor

Released:
DOI: 10.2210/pdb4lpf/pdb
PDB entry 4lpf coloured by chain, front view.
PDB entry 4lpf coloured by chain, side view.
PDB entry 4lpf coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Crystal structures of the native, substrate- bound and inhibited forms of Mycobacterium tuberculosis imidazole glycerol phosphate dehydratase
Ahangar MS, Vyas R, Nasir N, Biswal BK
Acta Crystallogr. D Biol. Crystallogr. (2013)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Imidazoleglycerol-phosphate dehydratase Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 23.63 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Mycolicibacterium smegmatis
Structure domains: Imidazole glycerol phosphate dehydratase; domain 1

Ligands and Environments

2 bound ligands:
Ligand 3TR 1 x 3TR
Ligand MN 3 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: P432
Unit cell:
a: 112.211Å b: 112.211Å c: 112.211Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.221
Expression system: Mycolicibacterium smegmatis

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