4l5b Summary details

pdbe.org/4l5b/summary_details
spacer Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor
Summary
Header transferase/transferase inhibitorsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.94 Å, R-factor: 19.001%, Free R-factor: 23.34%, Spacegroup: P 41
Released 18/09/2013, deposition: 10/06/2013, last revision: 27/11/2013
Authors Nomme, J.search; Lavie, A.search
Primary citation Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
J.MED.CHEM.search vol:56, pag:6696-6708 (2013) [PubMed 23947754 ]search
Keywords phosphoryl transfersearch, phosphorylationsearch, deoxycytidine kinasesearch, transferase-transferase inhibitor complexsearch
EC 2.7.1.74 ExPASy BRENDA search (A B)
Organism Homo sapiens(human) 9606search(A B)
UniProt P27707search (A B)
Solvent A, B
Related entries 4jlk
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A, B Deoxycytidine kinase Protein P27707 (DCK_HUMAN)search
280 82%
Heterogens
Chain Id Name Ligands
A, B 1-[5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]-2-METHYLPROPAN-2-OL 1UX search
A, B URIDINE-5'-DIPHOSPHATE UDP search
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