Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor
The structure was published by Murphy, J.M., Armijo, A.L., Nomme, J., et al., Jung, M.E., Lavie, A., and Radu, C.G., in 2013 in a paper entitled "Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.94 Å and deposited in 2013.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of Deoxycytidine kinase.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms homodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: