4l5b Summary


Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor

The structure was published by Murphy, J.M., Armijo, A.L., Nomme, J., et al., Jung, M.E., Lavie, A., and Radu, C.G., in 2013 in a paper entitled "Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.94 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Deoxycytidine kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Deoxycytidine kinase P27707 (1-260) (DCK_HUMAN)search Homo sapienssearch 93% 280 82%
B Deoxycytidine kinase P27707 (1-260) (DCK_HUMAN)search Homo sapienssearch 93% 280 82%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27707 (1 - 260) Deoxycytidine kinase Homo sapiens

Chain Sequence family (Pfam)
A, B (P27707) PF01712: Deoxynucleoside kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P27707) ATP bindingsearch nucleoside kinase activitysearch deoxycytidine kinase activitysearch drug bindingsearch kinase activitysearch nucleotide bindingsearch protein homodimerization activitysearch transferase activitysearch pyrimidine nucleobase metabolic processsearch deoxyribonucleoside monophosphate biosynthetic processsearch nucleotide biosynthetic processsearch small molecule metabolic processsearch purine nucleobase metabolic processsearch nucleobase-containing small molecule metabolic processsearch pyrimidine nucleotide metabolic processsearch pyrimidine nucleoside salvagesearch purine-containing compound salvagesearch phosphorylationsearch nucleobase-containing compound metabolic processsearch nucleussearch cytosolsearch

Chain InterPro annotation
A, B Deoxynucleoside kinasesearch P-loop containing nucleoside triphosphate hydrolasesearch