4l57 Summary


High resolutin structure of human cytosolic 5'(3')-deoxyribonucleotidase

The structure was published by Pachl, P., Fabry, M., Rosenberg, I., Simak, O., Rezacova, P., and Brynda, J., in 2014 in a paper entitled "Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.08 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of 5'(3')-deoxyribonucleotidase, cytosolic type.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 5'(3')-deoxyribonucleotidase, cytosolic type Q8TCD5 (1-195) (NT5C_HUMAN)search Homo sapienssearch 96% 195 98%
B 5'(3')-deoxyribonucleotidase, cytosolic type Q8TCD5 (1-195) (NT5C_HUMAN)search Homo sapienssearch 96% 195 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8TCD5 (1 - 195) 5'(3')-deoxyribonucleotidase, cytosolic type Homo sapiens

Chain Sequence family (Pfam)
A, B (Q8TCD5) PF06941: 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q8TCD5) nucleotide bindingsearch nucleotidase activitysearch 5'-nucleotidase activitysearch hydrolase activitysearch phosphatase activitysearch pyrimidine nucleotide bindingsearch metal ion bindingsearch nucleussearch cytoplasmsearch mitochondrionsearch cytosolsearch extracellular vesicular exosomesearch purine nucleobase metabolic processsearch purine nucleotide catabolic processsearch pyrimidine nucleobase metabolic processsearch nucleotide metabolic processsearch pyrimidine deoxyribonucleotide catabolic processsearch deoxyribonucleotide catabolic processsearch dephosphorylationsearch small molecule metabolic processsearch pyrimidine nucleoside catabolic processsearch nucleobase-containing small molecule metabolic processsearch

Chain InterPro annotation
A, B 5'(3')-deoxyribonucleotidasesearch HAD-like domainsearch