4l3q Summary


Crystal structure of glucokinase-activator complex

The structure was published by Filipski, K.J., Guzman-Perez, A., Bian, J., et al., Johnson, T.O., Humphries, P.S., and Pfefferkorn, J.A., in 2013 in a paper entitled "Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 457 residues which is 97% of the natural sequence. Out of 457 residues 447 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 457 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P35557) ATP bindingsearch magnesium ion bindingsearch glucose bindingsearch protein bindingsearch fructokinase activitysearch hexokinase activitysearch phosphotransferase activity, alcohol group as acceptorsearch glucokinase activitysearch kinase activitysearch nucleotide bindingsearch ADP bindingsearch catalytic activitysearch protein phosphatase bindingsearch transferase activitysearch mannokinase activitysearch cytosolsearch nucleussearch cytoplasmsearch cell cortexsearch nucleoplasmsearch secretory granulesearch mitochondrionsearch negative regulation of epinephrine secretionsearch small molecule metabolic processsearch cellular response to glucose starvationsearch cellular response to insulin stimulussearch phosphorylationsearch carbohydrate metabolic processsearch cellular glucose homeostasissearch endocrine pancreas developmentsearch glucose 6-phosphate metabolic processsearch glycogen biosynthetic processsearch NADP metabolic processsearch positive regulation of phosphorylationsearch transmembrane transportsearch glycolytic processsearch carbohydrate phosphorylationsearch regulation of insulin secretionsearch second-messenger-mediated signalingsearch calcium ion importsearch metabolic processsearch positive regulation of glycogen biosynthetic processsearch positive regulation of cytosolic calcium ion concentrationsearch glucose metabolic processsearch glucose homeostasissearch cellular response to leptin stimulussearch glucose transportsearch positive regulation of insulin secretionsearch negative regulation of gluconeogenesissearch hexose transportsearch regulation of glycolytic processsearch response to glucosesearch regulation of glucose transportsearch detection of glucosesearch positive regulation of glycolytic processsearch fructose 2,6-bisphosphate metabolic processsearch regulation of potassium ion transportsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch