› 4kzn

X-ray diffraction
1.71Å resolution

crystal structure of human VEGF-A receptor binding domain

Released:
DOI: 10.2210/pdb4kzn/pdb
PDB entry 4kzn coloured by chain, front view.
PDB entry 4kzn coloured by chain, side view.
PDB entry 4kzn coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Liaw YC

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147429 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
N-VEGF Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P15692 (Residues: 219-315; Coverage: 25%)
Gene names: VEGF, VEGFA
Structure domains: Cystine-knot cytokines

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
2 bound ligands:
Ligand PGE 1 x PGE
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1, NSRRC BEAMLINE BL13C1
Spacegroup: C2
Unit cell:
a: 87.573Å b: 32.014Å c: 42.981Å
α: 90° β: 92.99° γ: 90°
R-values:
R R work R free
0.183 0.179 0.218
Expression system: Drosophila melanogaster

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