4kro Summary

pdbe.org/4kro
spacer

Nanobody/VHH domain EgA1 in complex with the extracellular region of EGFR

The structure was published by Schmitz, K.R., Bagchi, A., Roovers, R.C., van Bergen En Henegouwen, P.M., and Ferguson, K.M., in 2013 in a paper entitled "Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.054 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Epidermal growth factor receptor P00533 (25-642) (EGFR_HUMAN)search Homo sapienssearch < 90% 624 91%
B Nanobody/VHH domain EgA1 Not available
Lama glamasearch Not available 138 84%
C Cetuximab light chain Not available
Mus musculussearch, Homo sapienssearch Not available 211 100%
D Cetuximab heavy chain Not available
Mus musculussearch, Homo sapienssearch Not available 220 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00533 (25 - 642) Epidermal growth factor receptor Homo sapiens

Chain Sequence family (Pfam)
A Furin-like cysteine rich regionsearch, Receptor L domainsearch, Growth factor receptor domain IVsearch
B
C
D

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00533) membranesearch transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch protein phosphorylationsearch

Chain InterPro annotation
A EGF receptor, L domainsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch
B Immunoglobulin V-set, subgroupsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
C Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
D Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch