› 4km9

X-ray diffraction
3.19Å resolution

Crystal structure of human Suppressor of Fused

Released:
DOI: 10.2210/pdb4km9/pdb
PDB entry 4km9 coloured by chain, front view.
PDB entry 4km9 coloured by chain, side view.
PDB entry 4km9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
Zhang Y, Fu L, Qi X, Zhang Z, Xia Y, Jia J, Jiang J, Zhao Y, Wu G
Nat Commun 4 2608 (2013)
PMID: 24217340

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193974 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Suppressor of fused homolog Chain: A
Molecule details ›
Chain: A
Length: 489 amino acids
Theoretical weight: 54.45 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9UMX1 (Residues: 1-484; Coverage: 100%)
Gene names: SUFU, UNQ650/PRO1280
Sequence domains:
Structure domains: Sufu, C-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 73.875Å b: 120.94Å c: 117.653Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.243 0.305
Expression system: Trichoplusia ni

Quick links

Citations

11 review citations

Hedgehog Signaling: From Basic Biology to Cancer Therapy.
Wu et al. (2017)
10 more

2 mentions without citation

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
Zhang et al. (2013)
1 more