› 4kgt

X-ray diffraction
2Å resolution

Backbone Modifications in the Protein GB1 Turns: Aib10, D-Pro47

Released:
DOI: 10.2210/pdb4kgt/pdb
PDB entry 4kgt coloured by chain, front view.
PDB entry 4kgt coloured by chain, side view.
PDB entry 4kgt coloured by chain, top view.
Source organism: Streptococcus sp. 'group G'
Primary publication:
Protein-like tertiary folding behavior from heterogeneous backbones.
Reinert ZE, Lengyel GA, Horne WS
J Am Chem Soc 135 12528-31 (2013)
PMID: 23937097

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin G-binding protein G Chains: A, B
Molecule details ›
Chains: A, B
Length: 55 amino acids
Theoretical weight: 5.83 KDa
Source organism: Streptococcus sp. 'group G'
Expression system: Not provided
UniProt:
  • Canonical: P06654 (Residues: 227-282; Coverage: 13%)
Gene name: spg
Sequence domains: B domain
Structure domains: Ubiquitin-like (UB roll)

Ligands and Environments

No bound ligands
2 modified residues:
Ligand AIB 2 x AIB
Ligand DPR 2 x DPR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: I4122
Unit cell:
a: 83.772Å b: 83.772Å c: 97.501Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.21
Expression system: Not provided

Quick links

Citations

7 review citations

Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns.
Horne et al. (2020)
6 more

4 mentions without citation

Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure.
Reinert et al. (2014)
3 more