4kbi Summary


HCV NS5B GT1B N316Y with CMPD 4

The structure was published by Maynard, A., Crosby, R.M., Ellis, B., et al., Xiong, Z.Z., Haigh, D., and Shotwell, J.B., in 2014 in a paper entitled "Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.06 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of HCV Polymerase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HCV Polymerase P26663 (2420-2989) (POLG_HCVBK)search Hepatitis C virus (isolate BK)search < 90% 580 93%
B HCV Polymerase P26663 (2420-2989) (POLG_HCVBK)search Hepatitis C virus (isolate BK)search < 90% 580 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P26663 (2420 - 2989) HCV Polymerase Hepatitis C virus subtype 1b

Chain Sequence family (Pfam)
A, B Viral RNA dependent RNA polymerasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P26663) viral RNA genome replicationsearch RNA bindingsearch RNA-directed RNA polymerase activitysearch

Chain InterPro annotation
A, B RNA dependent RNA polymerase, hepatitis C virussearch RNA-directed RNA polymerase, catalytic domainsearch