4k99 Summary

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Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppdG(2 ,5 )pdG

The structure was published by Gao, P., Ascano, M., Wu, Y., et al., Hartmann, G., Tuschl, T., and Patel, D.J., in 2013 in a paper entitled "Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Cyclic GMP-AMP synthase, DNA-F, and DNA-R.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cyclic GMP-AMP synthase Q8C6L5 (147-507) (CGAS_MOUSE)search Mus musculussearch < 90% 362 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8C6L5 (147 - 507) Cyclic GMP-AMP synthase Mus musculus

Chain Sequence family (Pfam)
A Mab-21 proteinsearch
Chain InterPro annotation
A Mab-21 domainsearch