4k5e Summary


Structure of neuronal nitric oxide synthase heme domain in complex with (R)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine

The structure was published by Jing, Q., Li, H., Chreifi, G., et al., Martasek, P., Poulos, T.L., and Silverman, R.B., in 2013 in a paper entitled "Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.892 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Nitric oxide synthase, brain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Nitric oxide synthase, brain P29476 (297-718) (NOS1_RAT)search Rattus norvegicussearch < 90% 422 97%
B Nitric oxide synthase, brain P29476 (297-718) (NOS1_RAT)search Rattus norvegicussearch < 90% 422 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29476 (297 - 718) Nitric oxide synthase, brain Rattus norvegicus

Chain Sequence family (Pfam)
A, B Nitric oxide synthase, oxygenase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P29476) nitric oxide biosynthetic processsearch oxidation-reduction processsearch nitric-oxide synthase activitysearch

Chain InterPro annotation
A, B Nitric oxide synthase, N-terminalsearch