spacer TL-3 inhibited Trp6Ala HIV Protease with 3-bromo-2,6-dimethoxybenzoic acid bound in flap site
UniProt
Accession P12499search
Name POL_HV1Z2
Keywords Virus exit from host cell, Zinc-finger, Eukaryotic host gene expression shutoff by virus, Host-virus interaction, Host nucleus, Endonuclease, Magnesium, Virion maturation, AIDS, Nucleotidyltransferase, DNA recombination, Virus entry into host cell, Hydrolase, Viral penetration into host nucleus, Host membrane, Host cytoplasm, DNA-directed DNA polymerase, Activation of host caspases by virus, Host cell membrane, Viral genome integration, Phosphoprotein, DNA integration, Aspartyl protease, Myristate, DNA-binding, Capsid protein, RNA-binding, Nuclease, Virion, Repeat, Ribosomal frameshifting, Membrane, Host gene expression shutoff by virus, RNA-directed DNA polymerase, Modulation of host cell apoptosis by virus, 3D-structure, Protease, Viral nucleoprotein, Metal-binding, Multifunctional enzyme, Transferase, Eukaryotic host translation shutoff by virus, Zinc, Lipoprotein
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Polymers A B
 
Enzyme nomenclature
EC number 3.1.26.13 ExPASy BRENDA search
Polymers A, B
Name retroviral ribonuclease H
Comment Retroviral reverse transcriptase is a multifunctional enzyme responsible for viral replication. To perform this task the enzyme combines two distinct activities. The polymerase domain (EC 2.7.7.49, RNA-directed DNA polymerase) occupies the N-terminal two-thirds of the reverse transcriptase whereas the ribonuclease H domain comprises the C-terminal remaining one-third [13,14]. The RNase H domain of Moloney murine leukemia virus and Human immunodeficiency virus display two metal binding sites [15-17].
EC number 3.1.13.2 ExPASy BRENDA search
Polymers B, A
Name exoribonuclease H, exoribonuclease H
Comment Attacks RNA in duplex with DNA strand. Found in certain oncorna viruses and animal cells.
This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC 3.1.26.13 (retroviral ribonuclease H).
EC number 2.7.7.49 ExPASy BRENDA search
Polymers A, B
Name RNA-directed DNA polymerase
Comment Catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC 2.7.7.7 DNA-directed DNA polymerase.
EC number 3.4.23.16 ExPASy BRENDA search
Polymers A, B
Name HIV-1 retropepsin
Comment Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses. Type example of peptidase family A2.
EC number 2.7.7.7 ExPASy BRENDA search
Polymers A, B
Name DNA-directed DNA polymerase
Comment Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
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