› 4jx3

X-ray diffraction
2.5Å resolution

Crystal structure of Pim1 kinase

Released:
DOI: 10.2210/pdb4jx3/pdb
PDB entry 4jx3 coloured by chain, front view.
PDB entry 4jx3 coloured by chain, side view.
PDB entry 4jx3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.
Lee SJ, Han BG, Cho JW, Choi JS, Lee J, Song HJ, Koh JS, Lee BI
PLoS One 8 e70358 (2013)
PMID: 23936194

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 326 amino acids
Theoretical weight: 37.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11309 (Residues: 1-313; Coverage: 100%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6C1
Spacegroup: P65
Unit cell:
a: 97.624Å b: 97.624Å c: 80.621Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.221 0.249
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Targeting Pim kinases for cancer treatment: opportunities and challenges.
Le et al. (2015)
1 more

5 mentions without citation

Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species.
Liu et al. (2021)
4 more