4jvf Summary details

pdbe.org/4jvf/summary_details
spacer The Crystal structure of PDE6D in complex with the inhibitor (s)-5
Summary
Header Protein binding/inhibitorsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.4 Å, R-factor: 20.949%, Free R-factor: 25.659%, Spacegroup: P 32 2 1
Released 22/05/2013, deposition: 25/03/2013, last revision: 05/06/2013
Authors Gunther, Z.search; Papke, B.search; Ismail, S.search; Vartak, N.search; Chandra, A.search; Hoffmann, M.search; Hahn, S.search; Triola, G.search; Wittinghofer, A.search; Bastiaens, P.search; Waldmann, H.search
Primary citation Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
NATUREsearch vol:497, pag:638-642 (2013) [PubMed 23698361 ]search
Keywords Immunoglobulin-like beta-sandwichsearch, GDI-like solubilizing factorsearch, Prenyl bindingsearch, Protein binding-inhibitor complexsearch
Organism Homo sapiens(human) 9606search(B)
UniProt O43924search (B)
Solvent B
Related entries 4jv6, 4jv8, 4jvb
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
B Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta Protein O43924 (PDE6D_HUMAN)search
152 92%
Heterogens
Chain Id Name Ligands
B (2S)-2-(2-PHENYL-1H-BENZIMIDAZOL-1-YL)-2-(PIPERIDIN-4-YL)ETHYL 1-(1-BENZYL-1H-BENZIMIDAZOL-2-YL)PIPERIDINE-4-CARBOXYLATE 17X search
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