Crystal Structure of RIalpha(91-379) bound to HE33, a N6 di-propyl substituted cAMP analog
The structure was published by Brown, S.H., Cheng, C.Y., Saldanha, S.A., et al., Cottam, H.B., Sankaran, B., and Taylor, S.S., in 2013 in a paper entitled "Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.952 Å and deposited in 2013.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of cAMP-dependent protein kinase type I-alpha regulatory subunit. This molecule has the UniProt identifier P00514 (KAP0_BOVIN). The sample contained 288 residues which is < 90% of the natural sequence. Out of 288 residues 250 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: