4jss Summary


Human carbonic anhydrase II H94D bound to a bidentate inhibitor

The structure was published by Martin, D.P., Hann, Z.S., and Cohen, S.M., in 2013 in a paper entitled "Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) metal ion bindingsearch protein bindingsearch zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch cytosolsearch myelin sheathsearch cytoplasmsearch plasma membranesearch extracellular spacesearch microvillussearch extracellular vesicular exosomesearch apical part of cellsearch basolateral plasma membranesearch membranesearch axonsearch cellular response to fluid shear stresssearch positive regulation of synaptic transmission, GABAergicsearch response to pHsearch positive regulation of dipeptide transmembrane transportsearch response to steroid hormonesearch regulation of intracellular pHsearch bicarbonate transportsearch response to organic substancesearch secretionsearch small molecule metabolic processsearch positive regulation of bone resorptionsearch positive regulation of cellular pH reductionsearch odontogenesis of dentin-containing toothsearch kidney developmentsearch response to estrogensearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch regulation of anion transportsearch regulation of chloride transportsearch morphogenesis of an epitheliumsearch response to zinc ionsearch one-carbon metabolic processsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch