Function and Biology

Crystal Structure of human SIRT3 with ELT inhibitor 11c [N-{2-[1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl]ethyl}-N'-ethylthiophene-2,5-dicarboxamide]

Source organism: Homo sapiens
Biochemical function: NAD+ binding
Biological process: not assigned
Cellular component: not assigned

EC 2.3.1.286: Protein acetyllysine N-acetyltransferase

Reaction catalysed:
(1a) [protein]-N(6)-acetyl-L-lysine + NAD(+) = [protein]-N(6)-(1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl)-L-lysine + nicotinamide
Systematic name:
[Protein]-N(6)-acetyl-L-lysine:NAD(+) N-acetyltransferase (NAD(+)-hydrolyzing; 2''-O-acetyl-ADP-D-ribose-forming)
Alternative Name(s):
  • NAD(+)-dependent protein deacetylase
  • Protein lysine deacetylase
  • Sir2

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02146
Domain description: Sir2 family
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
The deposited structure of PDB entry 4jsr contains 1 copy of Pfam domain PF02146 (Sir2 family) in NAD-dependent protein deacetylase sirtuin-3, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR026591
Domain description: Sirtuin, catalytic core small domain superfamily
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
IPR003000
Domain description: Sirtuin family
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
IPR029035
Domain description: DHS-like NAD/FAD-binding domain superfamily
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
IPR026590
Domain description: Sirtuin family, catalytic core domain
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
IPR017328
Domain description: Sirtuin, class I
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Structure domains

CATH CATH domains
3.40.50.1220
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: TPP-binding domain
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
The deposited structure of PDB entry 4jsr contains 1 copy of CATH domain 3.40.50.1220 (Rossmann fold) in NAD-dependent protein deacetylase sirtuin-3, mitochondrial. Showing 1 copy in chain A.
3.30.1600.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SIR2/SIRT2 'Small Domain'
Homology: SIR2/SIRT2 'Small Domain'
Occurring in:
  1. NAD-dependent protein deacetylase sirtuin-3, mitochondrial
The deposited structure of PDB entry 4jsr contains 1 copy of CATH domain 3.30.1600.10 (SIR2/SIRT2 'Small Domain') in NAD-dependent protein deacetylase sirtuin-3, mitochondrial. Showing 1 copy in chain A.