4jq8 Summary

pdbe.org/4jq8
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Crystal structure of EGFR kinase domain in complex with compound 4b

The structure was published by Peng, Y.H., Shiao, H.Y., Tu, C.H., et al., Lyu, P.C., Hsieh, H.P., and Wu, S.Y., in 2013 in a paper entitled "Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.83 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Epidermal growth factor receptor. This molecule has the UniProt identifier P00533 (EGFR_HUMAN)search. The sample contained 328 residues which is < 90% of the natural sequence. Out of 328 residues 302 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Epidermal growth factor receptor P00533 (696-1021) (EGFR_HUMAN)search Homo sapienssearch < 90% 328 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00533 (696 - 1021) Epidermal growth factor receptor Homo sapiens

Chain Sequence family (Pfam)
A Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P00533) protein tyrosine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch