4jnl Summary details

pdbe.org/4jnl/summary_details
spacer Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 7.4
Summary
Header HYDROLASE/HYDROLASE INHIBITORsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.0 Å, R-factor: 20.06%, Free R-factor: 25.2%, Spacegroup: H 3
Released 19/03/2014, deposition: 15/03/2013, last revision: 19/03/2014
Authors Zhang, X.search; Jiang, L.search; Zhao, B.search; Yuan, C.search; Huang, M.search
Primary citation Halogen bonds in the design of serine protease inhibitors
to be published
Keywords uPAsearch, halogensearch, HYDROLASE-HYDROLASE INHIBITOR complexsearch
EC 3.4.21.73 ExPASy BRENDA search (U)
Organism Homo sapiens(human) 9606search(U)
UniProt P00749search (U)
Solvent U
Related entries 4jni
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
U Urokinase-type plasminogen activator Protein P00749 (UROK_HUMAN)search
247 99%
Heterogens
Chain Id Name Ligands
U 1-(4-BROMOPHENYL)METHANAMINE PZH search
U SULFATE ION SO4 search
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