4jnl Summary


Crystal Structure of uPA in complex with its inhibitor 4-bromobenzylamine at pH 7.4

The structure was published by Zhang, X., Jiang, L., Zhao, B., Yuan, C., and Huang, M., in in a paper entitled "Halogen bonds in the design of serine protease inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Urokinase-type plasminogen activator. This molecule has the UniProt identifier P00749 (UROK_HUMAN)search. The sample contained 247 residues which is < 90% of the natural sequence. Out of 247 residues 246 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
U Urokinase-type plasminogen activator P00749 (179-425) (UROK_HUMAN)search Homo sapienssearch < 90% 247 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00749 (179 - 425) Urokinase-type plasminogen activator Homo sapiens

Chain Sequence family (Pfam)
U Trypsinsearch

Chain ID Molecular function (GO) Biological process (GO)
U (P00749) serine-type endopeptidase activitysearch catalytic activitysearch proteolysissearch

Chain InterPro annotation
U Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch