4jin Summary


X-ray crystal structure of Archaeoglobus fulgidus Rio1 bound to (2E)-N-benzyl-2-cyano-3-(pyridine-4-yl)acrylamide (WP1086)

The structure was published by Mielecki, M., Krawiec, K., Kiburu, I., et al., Priebe, W., Lesyng, B., and Laronde-Leblanc, N., in 2013 in a paper entitled "Development of novel molecular probes of the Rio1 atypical protein kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.095 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of RIO-type serine/threonine-protein kinase Rio1. This molecule has the UniProt identifier O28471 (RIO1_ARCFU)search. The sample contained 258 residues which is 100% of the natural sequence. Out of 258 residues 250 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RIO-type serine/threonine-protein kinase Rio1 O28471 (1-258) (RIO1_ARCFU)search Archaeoglobus fulgidus DSM 4304search 100% 258 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O28471 (1 - 258) RIO-type serine/threonine-protein kinase Rio1 Archaeoglobus fulgidus DSM 4304

Chain Sequence family (Pfam)
A (O28471) PF01163: RIO1 familysearch

Chain ID Molecular function (GO) Biological process (GO)
A (O28471) protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch nucleotide bindingsearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch kinase activitysearch metal ion bindingsearch catalytic activitysearch phosphorylationsearch protein phosphorylationsearch

Chain InterPro annotation
A RIO kinasesearch Protein kinase domainsearch Protein kinase-like domainsearch RIO domainsearch RIO kinase, conserved sitesearch