4jgc Summary


Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)

The structure was published by Hashimoto, H., Zhang, X., and Cheng, X., in 2013 in a paper entitled "Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.582 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely G/T mismatch-specific thymine DNA glycosylase, oligonucleotide, and oligonucleotide containing 5-carboxylcytosine.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A G/T mismatch-specific thymine DNA glycosylase Q13569 (111-308) (TDG_HUMAN)search Homo sapienssearch < 90% 204 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13569 (111 - 308) G/T mismatch-specific thymine DNA glycosylase Homo sapiens

Chain Sequence family (Pfam)
A Uracil DNA glycosylase superfamilysearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q13569) hydrolase activity, hydrolyzing N-glycosyl compoundssearch mismatched DNA bindingsearch hydrolase activity, acting on glycosyl bondssearch mismatch repairsearch DNA repairsearch

Chain InterPro annotation
A Thymine-DNA glycosylasesearch Uracil-DNA glycosylase-likesearch DNA glycosylase, G/T mismatchsearch