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Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)

Source organism: Homo sapiens
Biochemical function: mismatch base pair DNA N-glycosylase activity
Biological process: base-excision repair, AP site formation
Cellular component: not assigned

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EC 3.2.2.29: Thymine-DNA glycosylase

Reaction catalysed:
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine
Systematic name:
Thymine-DNA deoxyribohydrolase (thymine-releasing)
Alternative Name(s):
  • G/T glycosylase
  • G:T mismatch-specific thymine DNA-glycosylase
  • HTDG
  • HsTDG
  • Mismatch-specific thymine-DNA N-glycosylase
  • Mismatch-specific thymine-DNA glycosylase
  • T:G mismatch-specific thymidine-DNA glycosylase
  • TDG
  • Thymine DNA glycosylase
  • Uracil/thymine DNA glycosylase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF03167
Domain description: Uracil DNA glycosylase superfamily
Occurring in:
  1. G/T mismatch-specific thymine DNA glycosylase
The deposited structure of PDB entry 4jgc contains 1 copy of Pfam domain PF03167 (Uracil DNA glycosylase superfamily) in G/T mismatch-specific thymine DNA glycosylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015637
Domain description: Uracil DNA glycosylase family 2
Occurring in:
  1. G/T mismatch-specific thymine DNA glycosylase
IPR036895
Domain description: Uracil-DNA glycosylase-like domain superfamily
Occurring in:
  1. G/T mismatch-specific thymine DNA glycosylase
IPR005122
Domain description: Uracil-DNA glycosylase-like
Occurring in:
  1. G/T mismatch-specific thymine DNA glycosylase
IPR003310
Domain description: G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotes
Occurring in:
  1. G/T mismatch-specific thymine DNA glycosylase

Structure domain

CATH CATH domain
3.40.470.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Uracil-DNA Glycosylase, subunit E
Homology: Uracil-DNA glycosylase-like domain
Occurring in:
  1. G/T mismatch-specific thymine DNA glycosylase
The deposited structure of PDB entry 4jgc contains 1 copy of CATH domain 3.40.470.10 (Uracil-DNA Glycosylase, subunit E) in G/T mismatch-specific thymine DNA glycosylase. Showing 1 copy in chain A.

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