4jf7 Summary

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Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain

The structure was published by Welch, B.D., Yuan, P., Bose, S., Kors, C.A., Lamb, R.A., and Jardetzky, T.S., in 2013 in a paper entitled "Structure of the Parainfluenza Virus 5 (PIV5) Hemagglutinin-Neuraminidase (HN) Ectodomain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5018 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Hemagglutinin-neuraminidase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
D Hemagglutinin-neuraminidase P04850 (56-565) (HN_SV5)search Simian virus 5 (strain W3)search 90% 513 97%
A Hemagglutinin-neuraminidase P04850 (56-565) (HN_SV5)search Simian virus 5 (strain W3)search 90% 513 97%
B Hemagglutinin-neuraminidase P04850 (56-565) (HN_SV5)search Simian virus 5 (strain W3)search 90% 513 97%
C Hemagglutinin-neuraminidase P04850 (56-565) (HN_SV5)search Simian virus 5 (strain W3)search 90% 513 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04850 (56 - 565) Hemagglutinin-neuraminidase Simian virus 5 (strain W3)

Chain Sequence family (Pfam)
D, A, B, C (P04850) PF00423: Haemagglutinin-neuraminidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
D, A, B, C (P04850) viral life cyclesearch viral entry into host cellsearch metabolic processsearch viral processsearch virion attachment to host cellsearch exo-alpha-(2->3)-sialidase activitysearch exo-alpha-sialidase activitysearch host cell surface receptor bindingsearch exo-alpha-(2->6)-sialidase activitysearch hydrolase activitysearch exo-alpha-(2->8)-sialidase activitysearch host cell plasma membranesearch viral envelopesearch integral component of membranesearch virion membranesearch membranesearch virionsearch host cell membranesearch

Chain InterPro annotation
D, A, B, C Haemagglutinin-neuraminidasesearch Sialidasessearch