4jf7 Summary

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Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain

The structure was published by Welch, B.D., Yuan, P., Bose, S., Kors, C.A., Lamb, R.A., and Jardetzky, T.S., in 2013 in a paper entitled "Structure of the Parainfluenza Virus 5 (PIV5) Hemagglutinin-Neuraminidase (HN) Ectodomain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5018 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Hemagglutinin-neuraminidase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
D Hemagglutinin-neuraminidase P04850 (56-565) (HN_SV5)search Simian virus 5 (strain W3)search 90% 513 97%
A Hemagglutinin-neuraminidase P04850 (56-565) (HN_SV5)search Simian virus 5 (strain W3)search 90% 513 97%
B Hemagglutinin-neuraminidase P04850 (56-565) (HN_SV5)search Simian virus 5 (strain W3)search 90% 513 97%
C Hemagglutinin-neuraminidase P04850 (56-565) (HN_SV5)search Simian virus 5 (strain W3)search 90% 513 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04850 (56 - 565) Hemagglutinin-neuraminidase Simian virus 5 (strain W3)

Chain Sequence family (Pfam)
D, A, B, C (P04850) PF00423: Haemagglutinin-neuraminidasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
D, A, B, C (P04850) exo-alpha-sialidase activitysearch host cell surface receptor bindingsearch exo-alpha-(2->8)-sialidase activitysearch hydrolase activitysearch exo-alpha-(2->3)-sialidase activitysearch exo-alpha-(2->6)-sialidase activitysearch host cell plasma membranesearch viral envelopesearch membranesearch host cell membranesearch virion membranesearch virionsearch integral component of membranesearch viral entry into host cellsearch viral processsearch virion attachment to host cellsearch metabolic processsearch viral life cyclesearch

Chain InterPro annotation
D, A, B, C Haemagglutinin-neuraminidasesearch Sialidasessearch