4jap Summary details

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spacer Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.833 Å, R-factor: 23.68%, Free R-factor: 28.9%, Spacegroup: P 1 21 1
Released 24/04/2013, deposition: 19/02/2013, last revision: 27/11/2013
Authors Gokulan, K.search; Sacchettini, J.C.search; Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)search
Primary citation Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
J.BIOL.CHEM.search vol:288, pag:16484-16494 (2013) [PubMed 23615910 ]search
Keywords lipid biosynthesissearch, Structural Genomicssearch, Enzyme Function Initiativesearch, ketosynthase enzymesearch, Alkylpyrone synthesissearch, TRANSFERASEsearch
EC 2.3.1.- ExPASy BRENDA search (D C B A)
Organism Mycobacterium tuberculosis 1773search(D C B A)
UniProt P9WPF2search (D C B A)
Solvent A, B, C, D
Related entries 4jao, 4jaq, 4jar, 4jat, 4jd3
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
D, C, B, A Alpha-pyrone synthesis polyketide synthase-like Pks11 Protein P9WPF2 (PKS11_MYCTO)search
353 100%
Heterogens
Chain Id Name Ligands
D, C PALMITIC ACID PLM search
C, B COENZYME A COA search
B, A (2S)-2-METHYL-3-OXOOCTADECANOIC ACID 14U search
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