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Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones

The structure was published by Gokulan, K., O'Leary, S.E., Russell, W.K., et al., Begley, T.P., Ioerger, T.R., and Sacchettini, J.C., in 2013 in a paper entitled "Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.833 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Alpha-pyrone synthesis polyketide synthase-like Pks11.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
D Alpha-pyrone synthesis polyketide synthase-like Pks11 P9WPF2 (1-353) (PKS11_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 353 100%
C Alpha-pyrone synthesis polyketide synthase-like Pks11 P9WPF2 (1-353) (PKS11_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 353 100%
B Alpha-pyrone synthesis polyketide synthase-like Pks11 P9WPF2 (1-353) (PKS11_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 353 100%
A Alpha-pyrone synthesis polyketide synthase-like Pks11 P9WPF2 (1-353) (PKS11_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 353 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WPF2 (1 - 353) Alpha-pyrone synthesis polyketide synthase-like Pks11 Mycobacterium tuberculosis

Chain ID Molecular function (GO) Biological process (GO)
D, C, B, A (P9WPF2) transferase activity, transferring acyl groups other than amino-acyl groupssearch transferase activity, transferring acyl groupssearch catalytic activitysearch transferase activitysearch biosynthetic processsearch metabolic processsearch lipid metabolic processsearch fatty acid biosynthetic processsearch fatty acid metabolic processsearch

Chain InterPro annotation
D, C, B, A Chalcone/stilbene synthase, N-terminalsearch Polyketide synthase, type IIIsearch Chalcone/stilbene synthase, C-terminalsearch Thiolase-like, subgroupsearch Thiolase-likesearch