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Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones

The structure was published by Gokulan, K., O'Leary, S.E., Russell, W.K., et al., Begley, T.P., Ioerger, T.R., and Sacchettini, J.C., in 2013 in a paper entitled "Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Alpha-pyrone synthesis polyketide synthase-like Pks11.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
D Alpha-pyrone synthesis polyketide synthase-like Pks11 P9WPF2 (1-353) (PKS11_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 353 99%
C Alpha-pyrone synthesis polyketide synthase-like Pks11 P9WPF2 (1-353) (PKS11_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 353 99%
B Alpha-pyrone synthesis polyketide synthase-like Pks11 P9WPF2 (1-353) (PKS11_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 353 99%
A Alpha-pyrone synthesis polyketide synthase-like Pks11 P9WPF2 (1-353) (PKS11_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 353 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WPF2 (1 - 353) Alpha-pyrone synthesis polyketide synthase-like Pks11 Mycobacterium tuberculosis

Chain ID Biological process (GO) Molecular function (GO)
D, C, B, A (P9WPF2) metabolic processsearch biosynthetic processsearch lipid metabolic processsearch fatty acid biosynthetic processsearch fatty acid metabolic processsearch transferase activity, transferring acyl groups other than amino-acyl groupssearch transferase activity, transferring acyl groupssearch catalytic activitysearch transferase activitysearch

Chain InterPro annotation
D, C, B, A Chalcone/stilbene synthase, N-terminalsearch Polyketide synthase, type IIIsearch Chalcone/stilbene synthase, C-terminalsearch Thiolase-like, subgroupsearch Thiolase-likesearch