› 4j9c

X-ray diffraction
1.05Å resolution

Crystal structure of the Abl-SH3 domain H59Q-N96T mutant complexed with the designed high-affinity peptide ligand P17

Released:
DOI: 10.2210/pdb4j9c/pdb
PDB entry 4j9c coloured by chain, front view.
PDB entry 4j9c coloured by chain, side view.
PDB entry 4j9c coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Camara-Artigas A

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132614 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase ABL1 Chain: A
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 6.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00519 (Residues: 60-121; Coverage: 6%)
Gene names: ABL, ABL1, JTK7
Sequence domains: SH3 domain
Structure domains: SH3 Domains
P17 Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.07 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand PGE 1 x PGE
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3212
Unit cell:
a: 49.646Å b: 49.646Å c: 45.41Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.147 0.146 0.162
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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