The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a
The structure was published by Vu, B., Wovkulich, P., Pizzolato, G., et al., Packman, K., Vassilev, L., and Graves, B., in 2013 in a paper entitled "Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.91 Å and deposited in 2013.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of E3 ubiquitin-protein ligase Mdm2. This molecule has the UniProt identifier P56273 (MDM2_XENLA). The sample contained 86 residues which is < 90% of the natural sequence. Out of 86 residues 86 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: