› 4j23

X-ray diffraction
3.88Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 25.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 147-366; Coverage: 28%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains:
Structure domains: Immunoglobulins
Fibroblast growth factor 1 Chain: B
Molecule details ›
Chain: B
Length: 138 amino acids
Theoretical weight: 15.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05230 (Residues: 21-155; Coverage: 87%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P6222
Unit cell:
a: 210.674Å b: 210.674Å c: 72.512Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.324 0.321 0.384
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer.
Welti et al. (2013)
27 more

3 mentions without citation

A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe.
Liu et al. (2021)
2 more