4j02 Summary


Crystal structure of hcv ns5b polymerase in complex with [(1R)-5,8-DICHLORO-1-PROPYL-1,3,4,9-TETRAHYDROPYRANO[3,4-B]INDOL-1-YL]ACETIC ACID

The structure was published by Stammers, T.A., Coulombe, R., Rancourt, J., et al., Thauvette, L., Kukolj, G., and Beaulieu, P.L., in 2013 in a paper entitled "Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Genome polyprotein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Genome polyprotein O92972 (2420-2989) (POLG_HCVJ4)search Hepatitis C virus isolate HC-J4search < 90% 576 97%
B Genome polyprotein O92972 (2420-2989) (POLG_HCVJ4)search Hepatitis C virus isolate HC-J4search < 90% 576 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O92972 (2420 - 2989) Genome polyprotein Hepatitis C virus isolate HC-J4

Chain Sequence family (Pfam)
A, B Viral RNA dependent RNA polymerasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (O92972) viral RNA genome replicationsearch RNA-directed RNA polymerase activitysearch RNA bindingsearch

Chain InterPro annotation
A, B RNA dependent RNA polymerase, hepatitis C virussearch RNA-directed RNA polymerase, catalytic domainsearch