4ixc Summary


Crystal structure of Human Glucokinase in complex with a small molecule activator.

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P35557) fructokinase activitysearch mannokinase activitysearch nucleotide bindingsearch magnesium ion bindingsearch catalytic activitysearch glucokinase activitysearch hexokinase activitysearch protein bindingsearch ATP bindingsearch glucose bindingsearch kinase activitysearch transferase activitysearch phosphotransferase activity, alcohol group as acceptorsearch protein phosphatase bindingsearch ADP bindingsearch cellular glucose homeostasissearch carbohydrate metabolic processsearch glycogen biosynthetic processsearch fructose 2,6-bisphosphate metabolic processsearch glucose metabolic processsearch glycolytic processsearch regulation of glycolytic processsearch NADP metabolic processsearch positive regulation of cytosolic calcium ion concentrationsearch metabolic processsearch hexose transportsearch pathogenesissearch response to glucosesearch regulation of glucose transportsearch glucose transportsearch phosphorylationsearch second-messenger-mediated signalingsearch endocrine pancreas developmentsearch positive regulation of insulin secretionsearch negative regulation of epinephrine secretionsearch cellular response to insulin stimulussearch cellular response to glucose starvationsearch positive regulation of phosphorylationsearch glucose homeostasissearch regulation of potassium ion transportsearch small molecule metabolic processsearch cellular response to leptin stimulussearch negative regulation of gluconeogenesissearch positive regulation of glycogen biosynthetic processsearch positive regulation of glycolytic processsearch carbohydrate phosphorylationsearch regulation of insulin secretionsearch glucose 6-phosphate metabolic processsearch detection of glucosesearch transmembrane transportsearch lipid homeostasissearch calcium ion importsearch nucleussearch nucleoplasmsearch cytoplasmsearch mitochondrionsearch cytosolsearch actin filamentsearch cell cortexsearch secretory granulesearch basal cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch