4ixc Summary


Crystal structure of Human Glucokinase in complex with a small molecule activator.

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P35557) ATP bindingsearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch glucokinase activitysearch catalytic activitysearch fructokinase activitysearch kinase activitysearch protein bindingsearch magnesium ion bindingsearch ADP bindingsearch nucleotide bindingsearch mannokinase activitysearch glucose bindingsearch transferase activitysearch protein phosphatase bindingsearch carbohydrate metabolic processsearch cellular glucose homeostasissearch transmembrane transportsearch positive regulation of insulin secretionsearch second-messenger-mediated signalingsearch glucose 6-phosphate metabolic processsearch glucose metabolic processsearch response to glucosesearch positive regulation of phosphorylationsearch positive regulation of glycolytic processsearch detection of glucosesearch cellular response to insulin stimulussearch regulation of glucose transportsearch small molecule metabolic processsearch pathogenesissearch calcium ion importsearch endocrine pancreas developmentsearch cellular response to leptin stimulussearch regulation of insulin secretionsearch negative regulation of epinephrine secretionsearch regulation of glycolytic processsearch fructose 2,6-bisphosphate metabolic processsearch regulation of potassium ion transportsearch negative regulation of gluconeogenesissearch glucose homeostasissearch carbohydrate phosphorylationsearch metabolic processsearch NADP metabolic processsearch phosphorylationsearch glycogen biosynthetic processsearch glycolytic processsearch lipid homeostasissearch positive regulation of glycogen biosynthetic processsearch glucose transportsearch hexose transportsearch positive regulation of cytosolic calcium ion concentrationsearch cellular response to glucose starvationsearch secretory granulesearch cytoplasmsearch cytosolsearch actin filamentsearch nucleoplasmsearch cell cortexsearch mitochondrionsearch nucleussearch basal cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch