4ixc Summary


Crystal structure of Human Glucokinase in complex with a small molecule activator.

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P35557) glycolytic processsearch regulation of potassium ion transportsearch cellular response to insulin stimulussearch pathogenesissearch fructose 2,6-bisphosphate metabolic processsearch regulation of insulin secretionsearch response to glucosesearch transmembrane transportsearch positive regulation of phosphorylationsearch second-messenger-mediated signalingsearch carbohydrate metabolic processsearch glucose 6-phosphate metabolic processsearch negative regulation of gluconeogenesissearch glucose homeostasissearch positive regulation of glycolytic processsearch NADP metabolic processsearch positive regulation of cytosolic calcium ion concentrationsearch hexose transportsearch endocrine pancreas developmentsearch positive regulation of insulin secretionsearch cellular response to leptin stimulussearch glucose transportsearch cellular response to glucose starvationsearch positive regulation of glycogen biosynthetic processsearch lipid homeostasissearch cellular glucose homeostasissearch metabolic processsearch negative regulation of epinephrine secretionsearch glycogen biosynthetic processsearch regulation of glucose transportsearch glucose metabolic processsearch calcium ion importsearch detection of glucosesearch carbohydrate phosphorylationsearch small molecule metabolic processsearch phosphorylationsearch regulation of glycolytic processsearch actin filamentsearch secretory granulesearch cytoplasmsearch cytosolsearch nucleussearch nucleoplasmsearch mitochondrionsearch basal cortexsearch cell cortexsearch mannokinase activitysearch protein bindingsearch ATP bindingsearch glucose bindingsearch glucokinase activitysearch transferase activitysearch ADP bindingsearch nucleotide bindingsearch hexokinase activitysearch phosphotransferase activity, alcohol group as acceptorsearch magnesium ion bindingsearch fructokinase activitysearch catalytic activitysearch protein phosphatase bindingsearch kinase activitysearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch