4ixc Summary


Crystal structure of Human Glucokinase in complex with a small molecule activator.

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P35557) ATP bindingsearch mannokinase activitysearch protein bindingsearch glucokinase activitysearch kinase activitysearch catalytic activitysearch phosphotransferase activity, alcohol group as acceptorsearch protein phosphatase bindingsearch ADP bindingsearch glucose bindingsearch fructokinase activitysearch transferase activitysearch magnesium ion bindingsearch nucleotide bindingsearch hexokinase activitysearch cytoplasmsearch nucleoplasmsearch cytosolsearch nucleussearch actin filamentsearch secretory granulesearch cell cortexsearch mitochondrionsearch basal cortexsearch calcium ion importsearch second-messenger-mediated signalingsearch cellular response to leptin stimulussearch NADP metabolic processsearch negative regulation of epinephrine secretionsearch regulation of glucose transportsearch regulation of insulin secretionsearch detection of glucosesearch positive regulation of insulin secretionsearch transmembrane transportsearch glycolytic processsearch carbohydrate metabolic processsearch fructose 2,6-bisphosphate metabolic processsearch positive regulation of phosphorylationsearch glucose metabolic processsearch lipid homeostasissearch small molecule metabolic processsearch endocrine pancreas developmentsearch glucose homeostasissearch cellular response to insulin stimulussearch phosphorylationsearch carbohydrate phosphorylationsearch cellular glucose homeostasissearch regulation of potassium ion transportsearch glucose 6-phosphate metabolic processsearch negative regulation of gluconeogenesissearch regulation of glycolytic processsearch cellular response to glucose starvationsearch glucose transportsearch positive regulation of glycolytic processsearch hexose transportsearch metabolic processsearch positive regulation of glycogen biosynthetic processsearch response to glucosesearch positive regulation of cytosolic calcium ion concentrationsearch glycogen biosynthetic processsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch