4ixc Summary


Crystal structure of Human Glucokinase in complex with a small molecule activator.

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) glycolytic processsearch carbohydrate metabolic processsearch fructose 2,6-bisphosphate metabolic processsearch negative regulation of epinephrine secretionsearch lipid homeostasissearch regulation of potassium ion transportsearch regulation of glucose transportsearch glycogen biosynthetic processsearch glucose 6-phosphate metabolic processsearch detection of glucosesearch cellular response to leptin stimulussearch small molecule metabolic processsearch glucose metabolic processsearch transmembrane transportsearch cellular glucose homeostasissearch positive regulation of phosphorylationsearch positive regulation of insulin secretionsearch pathogenesissearch cellular response to insulin stimulussearch phosphorylationsearch carbohydrate phosphorylationsearch glucose homeostasissearch NADP metabolic processsearch endocrine pancreas developmentsearch positive regulation of cytosolic calcium ion concentrationsearch regulation of insulin secretionsearch positive regulation of glycolytic processsearch response to glucosesearch regulation of glycolytic processsearch second-messenger-mediated signalingsearch hexose transportsearch glucose transportsearch negative regulation of gluconeogenesissearch metabolic processsearch calcium ion importsearch positive regulation of glycogen biosynthetic processsearch cellular response to glucose starvationsearch phosphotransferase activity, alcohol group as acceptorsearch ATP bindingsearch kinase activitysearch fructokinase activitysearch nucleotide bindingsearch glucokinase activitysearch mannokinase activitysearch catalytic activitysearch protein bindingsearch transferase activitysearch protein phosphatase bindingsearch glucose bindingsearch magnesium ion bindingsearch ADP bindingsearch hexokinase activitysearch cytosolsearch nucleoplasmsearch cytoplasmsearch basal cortexsearch nucleussearch secretory granulesearch actin filamentsearch cell cortexsearch mitochondrionsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch