4ixc Summary


Crystal structure of Human Glucokinase in complex with a small molecule activator.

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P35557) detection of glucosesearch positive regulation of glycolytic processsearch regulation of glucose transportsearch NADP metabolic processsearch second-messenger-mediated signalingsearch glucose metabolic processsearch carbohydrate phosphorylationsearch response to glucosesearch regulation of insulin secretionsearch fructose 2,6-bisphosphate metabolic processsearch glycogen biosynthetic processsearch transmembrane transportsearch cellular glucose homeostasissearch positive regulation of insulin secretionsearch metabolic processsearch negative regulation of epinephrine secretionsearch calcium ion importsearch small molecule metabolic processsearch endocrine pancreas developmentsearch glycolytic processsearch positive regulation of cytosolic calcium ion concentrationsearch glucose homeostasissearch lipid homeostasissearch cellular response to glucose starvationsearch positive regulation of phosphorylationsearch cellular response to leptin stimulussearch glucose 6-phosphate metabolic processsearch carbohydrate metabolic processsearch negative regulation of gluconeogenesissearch regulation of glycolytic processsearch cellular response to insulin stimulussearch regulation of potassium ion transportsearch positive regulation of glycogen biosynthetic processsearch glucose transportsearch hexose transportsearch phosphorylationsearch nucleoplasmsearch mitochondrionsearch cytosolsearch actin filamentsearch cytoplasmsearch nucleussearch cell cortexsearch basal cortexsearch secretory granulesearch ATP bindingsearch protein bindingsearch fructokinase activitysearch glucokinase activitysearch transferase activitysearch protein phosphatase bindingsearch kinase activitysearch glucose bindingsearch nucleotide bindingsearch mannokinase activitysearch magnesium ion bindingsearch hexokinase activitysearch catalytic activitysearch phosphotransferase activity, alcohol group as acceptorsearch ADP bindingsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch