4ixc Summary


Crystal structure of Human Glucokinase in complex with a small molecule activator.

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) transmembrane transportsearch positive regulation of phosphorylationsearch regulation of potassium ion transportsearch regulation of glycolysissearch glucose metabolic processsearch glycolysissearch carbohydrate metabolic processsearch positive regulation of glycogen biosynthetic processsearch glucose homeostasissearch carbohydrate phosphorylationsearch glycogen biosynthetic processsearch glucose 6-phosphate metabolic processsearch negative regulation of epinephrine secretionsearch cellular response to glucose starvationsearch positive regulation of insulin secretionsearch negative regulation of gluconeogenesissearch regulation of insulin secretionsearch NADP metabolic processsearch fructose 2,6-bisphosphate metabolic processsearch cellular glucose homeostasissearch glucose transportsearch detection of glucosesearch calcium ion importsearch hexose transportsearch elevation of cytosolic calcium ion concentrationsearch regulation of glucose transportsearch response to glucose stimulussearch endocrine pancreas developmentsearch cellular response to leptin stimulussearch phosphorylationsearch cellular response to insulin stimulussearch positive regulation of glycolysissearch metabolic processsearch small molecule metabolic processsearch second-messenger-mediated signalingsearch mannokinase activitysearch glucokinase activitysearch phosphotransferase activity, alcohol group as acceptorsearch ATP bindingsearch hexokinase activitysearch protein bindingsearch transferase activitysearch glucose bindingsearch ADP bindingsearch kinase activitysearch protein phosphatase bindingsearch catalytic activitysearch fructokinase activitysearch nucleotide bindingsearch magnesium ion bindingsearch cytoplasmsearch cytosolsearch nucleoplasmsearch nucleussearch secretory granulesearch mitochondrionsearch cell cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch