4ixc Summary


Crystal structure of Human Glucokinase in complex with a small molecule activator.

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) glycolytic processsearch positive regulation of insulin secretionsearch response to glucosesearch positive regulation of glycolytic processsearch hexose transportsearch positive regulation of glycogen biosynthetic processsearch cellular response to glucose starvationsearch carbohydrate phosphorylationsearch regulation of insulin secretionsearch endocrine pancreas developmentsearch carbohydrate metabolic processsearch glycogen biosynthetic processsearch calcium ion importsearch cellular glucose homeostasissearch cellular response to insulin stimulussearch glucose 6-phosphate metabolic processsearch regulation of potassium ion transportsearch transmembrane transportsearch phosphorylationsearch NADP metabolic processsearch positive regulation of cytosolic calcium ion concentrationsearch regulation of glucose transportsearch detection of glucosesearch metabolic processsearch small molecule metabolic processsearch cellular response to leptin stimulussearch glucose homeostasissearch fructose 2,6-bisphosphate metabolic processsearch positive regulation of phosphorylationsearch negative regulation of epinephrine secretionsearch regulation of glycolytic processsearch glucose metabolic processsearch negative regulation of gluconeogenesissearch glucose transportsearch second-messenger-mediated signalingsearch glucokinase activitysearch magnesium ion bindingsearch ATP bindingsearch glucose bindingsearch hexokinase activitysearch phosphotransferase activity, alcohol group as acceptorsearch kinase activitysearch catalytic activitysearch protein phosphatase bindingsearch mannokinase activitysearch protein bindingsearch nucleotide bindingsearch fructokinase activitysearch transferase activitysearch ADP bindingsearch cytosolsearch nucleoplasmsearch nucleussearch cell cortexsearch secretory granulesearch mitochondrionsearch cytoplasmsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch