4ixc Summary


Crystal structure of Human Glucokinase in complex with a small molecule activator.

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P35557) phosphotransferase activity, alcohol group as acceptorsearch ATP bindingsearch hexokinase activitysearch mannokinase activitysearch ADP bindingsearch kinase activitysearch glucokinase activitysearch protein bindingsearch transferase activitysearch protein phosphatase bindingsearch nucleotide bindingsearch glucose bindingsearch fructokinase activitysearch catalytic activitysearch magnesium ion bindingsearch glycolytic processsearch carbohydrate metabolic processsearch calcium ion importsearch glucose metabolic processsearch carbohydrate phosphorylationsearch positive regulation of insulin secretionsearch detection of glucosesearch transmembrane transportsearch regulation of glucose transportsearch negative regulation of epinephrine secretionsearch glucose 6-phosphate metabolic processsearch small molecule metabolic processsearch cellular glucose homeostasissearch glycogen biosynthetic processsearch endocrine pancreas developmentsearch metabolic processsearch regulation of potassium ion transportsearch glucose homeostasissearch positive regulation of glycolytic processsearch response to glucosesearch cellular response to insulin stimulussearch cellular response to glucose starvationsearch cellular response to leptin stimulussearch regulation of insulin secretionsearch NADP metabolic processsearch hexose transportsearch glucose transportsearch second-messenger-mediated signalingsearch positive regulation of cytosolic calcium ion concentrationsearch regulation of glycolytic processsearch negative regulation of gluconeogenesissearch phosphorylationsearch fructose 2,6-bisphosphate metabolic processsearch positive regulation of phosphorylationsearch positive regulation of glycogen biosynthetic processsearch mitochondrionsearch cytosolsearch nucleussearch nucleoplasmsearch cytoplasmsearch secretory granulesearch cell cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch