4ixc Summary


Crystal structure of Human Glucokinase in complex with a small molecule activator.

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) carbohydrate metabolic processsearch positive regulation of phosphorylationsearch fructose 2,6-bisphosphate metabolic processsearch response to glucosesearch positive regulation of insulin secretionsearch transmembrane transportsearch positive regulation of glycolytic processsearch cellular glucose homeostasissearch glucose homeostasissearch cellular response to leptin stimulussearch cellular response to glucose starvationsearch negative regulation of epinephrine secretionsearch positive regulation of cytosolic calcium ion concentrationsearch calcium ion importsearch small molecule metabolic processsearch metabolic processsearch endocrine pancreas developmentsearch regulation of glucose transportsearch glycolytic processsearch detection of glucosesearch carbohydrate phosphorylationsearch regulation of insulin secretionsearch regulation of potassium ion transportsearch regulation of glycolytic processsearch negative regulation of gluconeogenesissearch glucose metabolic processsearch cellular response to insulin stimulussearch second-messenger-mediated signalingsearch NADP metabolic processsearch phosphorylationsearch positive regulation of glycogen biosynthetic processsearch hexose transportsearch glycogen biosynthetic processsearch glucose 6-phosphate metabolic processsearch glucose transportsearch ATP bindingsearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch mannokinase activitysearch glucokinase activitysearch protein bindingsearch ADP bindingsearch magnesium ion bindingsearch transferase activitysearch glucose bindingsearch protein phosphatase bindingsearch fructokinase activitysearch catalytic activitysearch nucleotide bindingsearch kinase activitysearch nucleussearch cytosolsearch cytoplasmsearch nucleoplasmsearch mitochondrionsearch secretory granulesearch cell cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch