4iwv Summary

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Crystals structure of Human Glucokinase in complex with small molecule activator

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search; Flavell, L.search; McAlister, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) carbohydrate metabolic processsearch cellular response to leptin stimulussearch regulation of glucose transportsearch hexose transportsearch cellular response to insulin stimulussearch negative regulation of gluconeogenesissearch cellular response to glucose starvationsearch phosphorylationsearch carbohydrate phosphorylationsearch glycogen biosynthetic processsearch fructose 2,6-bisphosphate metabolic processsearch negative regulation of epinephrine secretionsearch glycolytic processsearch calcium ion importsearch response to glucosesearch glucose metabolic processsearch endocrine pancreas developmentsearch glucose homeostasissearch detection of glucosesearch cellular glucose homeostasissearch positive regulation of insulin secretionsearch metabolic processsearch regulation of insulin secretionsearch positive regulation of phosphorylationsearch small molecule metabolic processsearch glucose transportsearch positive regulation of glycolytic processsearch regulation of potassium ion transportsearch NADP metabolic processsearch second-messenger-mediated signalingsearch transmembrane transportsearch glucose 6-phosphate metabolic processsearch regulation of glycolytic processsearch positive regulation of glycogen biosynthetic processsearch positive regulation of cytosolic calcium ion concentrationsearch ATP bindingsearch glucose bindingsearch glucokinase activitysearch phosphotransferase activity, alcohol group as acceptorsearch transferase activitysearch mannokinase activitysearch protein bindingsearch fructokinase activitysearch hexokinase activitysearch ADP bindingsearch nucleotide bindingsearch magnesium ion bindingsearch catalytic activitysearch kinase activitysearch protein phosphatase bindingsearch cytosolsearch mitochondrionsearch nucleussearch cytoplasmsearch secretory granulesearch nucleoplasmsearch cell cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch