4iwv Summary


Crystals structure of Human Glucokinase in complex with small molecule activator

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search; Flavell, L.search; McAlister, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) carbohydrate metabolic processsearch glycolysissearch positive regulation of glycogen biosynthetic processsearch positive regulation of glycolysissearch carbohydrate phosphorylationsearch cellular response to insulin stimulussearch regulation of potassium ion transportsearch cellular response to leptin stimulussearch NADP metabolic processsearch glucose homeostasissearch regulation of insulin secretionsearch small molecule metabolic processsearch elevation of cytosolic calcium ion concentrationsearch glucose transportsearch glucose metabolic processsearch phosphorylationsearch endocrine pancreas developmentsearch detection of glucosesearch regulation of glycolysissearch second-messenger-mediated signalingsearch fructose 2,6-bisphosphate metabolic processsearch negative regulation of gluconeogenesissearch cellular response to glucose starvationsearch cellular glucose homeostasissearch hexose transportsearch transmembrane transportsearch positive regulation of phosphorylationsearch positive regulation of insulin secretionsearch calcium ion importsearch glucose 6-phosphate metabolic processsearch response to glucose stimulussearch glycogen biosynthetic processsearch negative regulation of epinephrine secretionsearch regulation of glucose transportsearch metabolic processsearch phosphotransferase activity, alcohol group as acceptorsearch ATP bindingsearch hexokinase activitysearch transferase activitysearch glucose bindingsearch ADP bindingsearch fructokinase activitysearch catalytic activitysearch kinase activitysearch glucokinase activitysearch protein bindingsearch mannokinase activitysearch protein phosphatase bindingsearch nucleotide bindingsearch magnesium ion bindingsearch nucleoplasmsearch mitochondrionsearch cytosolsearch secretory granulesearch cell cortexsearch cytoplasmsearch nucleussearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch