4iwv Summary

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Crystals structure of Human Glucokinase in complex with small molecule activator

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search; Flavell, L.search; McAlister, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P35557) ATP bindingsearch nucleotide bindingsearch glucokinase activitysearch kinase activitysearch protein phosphatase bindingsearch glucose bindingsearch mannokinase activitysearch fructokinase activitysearch protein bindingsearch catalytic activitysearch ADP bindingsearch phosphotransferase activity, alcohol group as acceptorsearch transferase activitysearch magnesium ion bindingsearch hexokinase activitysearch glycolytic processsearch second-messenger-mediated signalingsearch regulation of insulin secretionsearch detection of glucosesearch glucose 6-phosphate metabolic processsearch cellular glucose homeostasissearch phosphorylationsearch glucose homeostasissearch carbohydrate phosphorylationsearch positive regulation of insulin secretionsearch glycogen biosynthetic processsearch carbohydrate metabolic processsearch NADP metabolic processsearch positive regulation of glycolytic processsearch cellular response to leptin stimulussearch transmembrane transportsearch lipid homeostasissearch glucose metabolic processsearch glucose transportsearch positive regulation of phosphorylationsearch cellular response to insulin stimulussearch small molecule metabolic processsearch cellular response to glucose starvationsearch response to glucosesearch calcium ion importsearch regulation of potassium ion transportsearch metabolic processsearch regulation of glycolytic processsearch fructose 2,6-bisphosphate metabolic processsearch positive regulation of glycogen biosynthetic processsearch negative regulation of epinephrine secretionsearch positive regulation of cytosolic calcium ion concentrationsearch regulation of glucose transportsearch negative regulation of gluconeogenesissearch hexose transportsearch endocrine pancreas developmentsearch cytosolsearch cytoplasmsearch nucleussearch secretory granulesearch basal cortexsearch nucleoplasmsearch actin filamentsearch mitochondrionsearch cell cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch