4iwv Summary


Crystals structure of Human Glucokinase in complex with small molecule activator

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search; Flavell, L.search; McAlister, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P35557) phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch ATP bindingsearch glucokinase activitysearch transferase activitysearch ADP bindingsearch nucleotide bindingsearch mannokinase activitysearch magnesium ion bindingsearch glucose bindingsearch kinase activitysearch catalytic activitysearch fructokinase activitysearch protein bindingsearch protein phosphatase bindingsearch carbohydrate metabolic processsearch endocrine pancreas developmentsearch cellular glucose homeostasissearch glycogen biosynthetic processsearch detection of glucosesearch glucose homeostasissearch glucose metabolic processsearch positive regulation of glycolytic processsearch fructose 2,6-bisphosphate metabolic processsearch lipid homeostasissearch glycolytic processsearch positive regulation of insulin secretionsearch pathogenesissearch regulation of potassium ion transportsearch glucose 6-phosphate metabolic processsearch cellular response to leptin stimulussearch regulation of insulin secretionsearch glucose transportsearch cellular response to insulin stimulussearch small molecule metabolic processsearch phosphorylationsearch carbohydrate phosphorylationsearch transmembrane transportsearch calcium ion importsearch second-messenger-mediated signalingsearch positive regulation of glycogen biosynthetic processsearch regulation of glycolytic processsearch cellular response to glucose starvationsearch negative regulation of epinephrine secretionsearch metabolic processsearch NADP metabolic processsearch positive regulation of cytosolic calcium ion concentrationsearch response to glucosesearch positive regulation of phosphorylationsearch negative regulation of gluconeogenesissearch regulation of glucose transportsearch hexose transportsearch cytoplasmsearch nucleussearch cell cortexsearch nucleoplasmsearch cytosolsearch basal cortexsearch mitochondrionsearch secretory granulesearch actin filamentsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch