4iwv Summary


Crystals structure of Human Glucokinase in complex with small molecule activator

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search; Flavell, L.search; McAlister, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) carbohydrate metabolic processsearch endocrine pancreas developmentsearch negative regulation of epinephrine secretionsearch glucose homeostasissearch detection of glucosesearch glucose 6-phosphate metabolic processsearch positive regulation of insulin secretionsearch regulation of insulin secretionsearch metabolic processsearch glucose metabolic processsearch cellular glucose homeostasissearch carbohydrate phosphorylationsearch cellular response to insulin stimulussearch response to glucosesearch small molecule metabolic processsearch positive regulation of cytosolic calcium ion concentrationsearch glycogen biosynthetic processsearch glucose transportsearch second-messenger-mediated signalingsearch regulation of potassium ion transportsearch fructose 2,6-bisphosphate metabolic processsearch positive regulation of phosphorylationsearch transmembrane transportsearch glycolytic processsearch positive regulation of glycogen biosynthetic processsearch calcium ion importsearch phosphorylationsearch positive regulation of glycolytic processsearch cellular response to leptin stimulussearch regulation of glycolytic processsearch hexose transportsearch negative regulation of gluconeogenesissearch cellular response to glucose starvationsearch NADP metabolic processsearch regulation of glucose transportsearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch ATP bindingsearch glucokinase activitysearch kinase activitysearch mannokinase activitysearch fructokinase activitysearch protein phosphatase bindingsearch magnesium ion bindingsearch glucose bindingsearch protein bindingsearch ADP bindingsearch nucleotide bindingsearch catalytic activitysearch transferase activitysearch secretory granulesearch mitochondrionsearch cytosolsearch nucleussearch nucleoplasmsearch cell cortexsearch cytoplasmsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch