4iwv Summary

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Crystals structure of Human Glucokinase in complex with small molecule activator

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search; Flavell, L.search; McAlister, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) second-messenger-mediated signalingsearch regulation of potassium ion transportsearch transmembrane transportsearch positive regulation of glycogen biosynthetic processsearch glycogen biosynthetic processsearch glucose homeostasissearch carbohydrate phosphorylationsearch positive regulation of phosphorylationsearch regulation of glycolytic processsearch cellular response to leptin stimulussearch hexose transportsearch glycolytic processsearch glucose 6-phosphate metabolic processsearch glucose metabolic processsearch positive regulation of cytosolic calcium ion concentrationsearch regulation of glucose transportsearch positive regulation of glycolytic processsearch pathogenesissearch negative regulation of gluconeogenesissearch calcium ion importsearch cellular response to insulin stimulussearch carbohydrate metabolic processsearch endocrine pancreas developmentsearch positive regulation of insulin secretionsearch NADP metabolic processsearch fructose 2,6-bisphosphate metabolic processsearch response to glucosesearch cellular glucose homeostasissearch lipid homeostasissearch detection of glucosesearch phosphorylationsearch regulation of insulin secretionsearch metabolic processsearch small molecule metabolic processsearch negative regulation of epinephrine secretionsearch cellular response to glucose starvationsearch glucose transportsearch kinase activitysearch protein bindingsearch ATP bindingsearch nucleotide bindingsearch magnesium ion bindingsearch glucose bindingsearch fructokinase activitysearch glucokinase activitysearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch ADP bindingsearch catalytic activitysearch transferase activitysearch mannokinase activitysearch protein phosphatase bindingsearch nucleoplasmsearch cytosolsearch nucleussearch actin filamentsearch cytoplasmsearch cell cortexsearch mitochondrionsearch basal cortexsearch secretory granulesearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch