4iwv Summary


Crystals structure of Human Glucokinase in complex with small molecule activator

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search; Flavell, L.search; McAlister, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P35557) ATP bindingsearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch glucokinase activitysearch protein phosphatase bindingsearch fructokinase activitysearch mannokinase activitysearch glucose bindingsearch transferase activitysearch protein bindingsearch kinase activitysearch catalytic activitysearch nucleotide bindingsearch ADP bindingsearch magnesium ion bindingsearch carbohydrate metabolic processsearch detection of glucosesearch endocrine pancreas developmentsearch glucose homeostasissearch glucose metabolic processsearch positive regulation of insulin secretionsearch cellular glucose homeostasissearch glycolytic processsearch response to glucosesearch cellular response to leptin stimulussearch cellular response to insulin stimulussearch regulation of insulin secretionsearch metabolic processsearch glycogen biosynthetic processsearch carbohydrate phosphorylationsearch small molecule metabolic processsearch positive regulation of cytosolic calcium ion concentrationsearch glucose transportsearch NADP metabolic processsearch fructose 2,6-bisphosphate metabolic processsearch cellular response to glucose starvationsearch regulation of glycolytic processsearch positive regulation of glycogen biosynthetic processsearch transmembrane transportsearch phosphorylationsearch positive regulation of phosphorylationsearch hexose transportsearch regulation of glucose transportsearch negative regulation of epinephrine secretionsearch regulation of potassium ion transportsearch negative regulation of gluconeogenesissearch calcium ion importsearch positive regulation of glycolytic processsearch glucose 6-phosphate metabolic processsearch second-messenger-mediated signalingsearch nucleoplasmsearch mitochondrionsearch nucleussearch cell cortexsearch cytosolsearch cytoplasmsearch secretory granulesearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch