4iwv Summary


Crystals structure of Human Glucokinase in complex with small molecule activator

A publication describing this structure is not available. The depositing authors are Ogg, D.J.search; Hargreaves, D.search; Gerhardt, S.search; Flavell, L.search; McAlister, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase isoform 3. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 456 residues which is 97% of the natural sequence. Out of 456 residues 443 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase isoform 3 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 456 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase isoform 3 Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) carbohydrate metabolic processsearch endocrine pancreas developmentsearch glucose homeostasissearch detection of glucosesearch glucose 6-phosphate metabolic processsearch cellular glucose homeostasissearch regulation of insulin secretionsearch carbohydrate phosphorylationsearch positive regulation of insulin secretionsearch glycolytic processsearch glycogen biosynthetic processsearch cellular response to leptin stimulussearch cellular response to insulin stimulussearch positive regulation of glycolytic processsearch small molecule metabolic processsearch positive regulation of cytosolic calcium ion concentrationsearch calcium ion importsearch glucose transportsearch transmembrane transportsearch cellular response to glucose starvationsearch regulation of potassium ion transportsearch positive regulation of phosphorylationsearch metabolic processsearch phosphorylationsearch positive regulation of glycogen biosynthetic processsearch response to glucosesearch second-messenger-mediated signalingsearch negative regulation of epinephrine secretionsearch glucose metabolic processsearch NADP metabolic processsearch regulation of glycolytic processsearch fructose 2,6-bisphosphate metabolic processsearch regulation of glucose transportsearch negative regulation of gluconeogenesissearch hexose transportsearch lipid homeostasissearch phosphotransferase activity, alcohol group as acceptorsearch glucokinase activitysearch ATP bindingsearch transferase activitysearch mannokinase activitysearch kinase activitysearch fructokinase activitysearch magnesium ion bindingsearch glucose bindingsearch catalytic activitysearch ADP bindingsearch protein bindingsearch nucleotide bindingsearch protein phosphatase bindingsearch hexokinase activitysearch cytoplasmsearch mitochondrionsearch cytosolsearch nucleussearch basal cortexsearch secretory granulesearch nucleoplasmsearch actin filamentsearch cell cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch